The hotbars are actually seperated by a chatbox on my UI, but since I play in 1400x900 I figured I'd edit it for sanity.
My main combat hotbars are all on the left and, more or less, in the order I use them. '2' is a macro containing Lucky Break, Squeeze & scarring blow. '-' is a macro for Masked Strike & Puncture blade. 'A=' is a macro for Death Blow & Bounty. 'C0' is a macro for Ear shot & spine Shot. I use these macros both to free up hotbar realestate and because they are all things I use in combination anyway.
The right side is pretty much just storage for shit I seldom use or the items I dont wanna dig thru my bags/spellbook to find.
Cheers,
Oasis.Loxx