Got a pm for my hotbar setup, here they are and here's my logic.
Left
Bar 1 - Buffs, the shield is a macro to cast befuddle and off. stance, and no thats not yell its an assist macro
Bar 2 - Anywhere attacks and frontals, and ranged
Bar 3 - Primary Debuffs, Snares, the macros in front are dispatch related
Bar 4 - Positional Attacks, Short term buffs, deaggros
Right
Bar 5 - Misc crap ie manastone, hearts and shards, evac, track, calls
Bar 6 - Poisons, BPs to pop on the epitaphe and use it quick, potions, totems, ruffian master 1 muahahah -if only it ever got used!
Unless I need to get swipe up ASAP, I start down bar 3, then 4, then 1. I pretty much have played so long I know when stuff is coming back up ie sideswipe and shrouded, that im always hovering over them.