i went all the way to 80 STR specced.
was good DPS for the stuff we did, mostly EOF/RoK instances. always in top 2-3 on parses (only falling short of assassins and well played brigands)
once i hit 80, got lucky and looted
Ryjesium Forged Knuckles from CoA.
soon after, went after my epic (which can be done fairly quick with a good group).
boosted DPS a pretty decent amount (dropped STR went WIS), all without steppin foot in a raid zone.
and if ya hit RoK raids, Doomcoil's baton would be a repalcement to the Ryjesium knucks, and not that hard to get.
*edit* STR line > the 2-hander you get from anaphylaxis, from my experience/parses.