I mostly use mouse for casting and keyboard for moving cept for I have my MA and secondary/back up MA set for keyboard 1 and 2 so that I can grab target without having to move my mouse to an assist key.
The two hotbars to the side tend to have different things on them from time to time depending on what is needed for an encounter or something I may hotkey a weapon switch or an item ability or put fear on there for dueling or something.
I have my group window on the Left side of the screen now instead of the Right side too as I remember.