I use fetish as my UI. I find that Profit has too much clutter. Fetish also has click to cure.
The two bars stacked in the middle is the spells I use most often. Major DPS and Heal spells are on the bottom bar. The upper bar contains Energy Vortex, which is actually macroed on the first icon which allows me to press it and instantly start casting my nukes and dots. The upper bar also contains miracles and debuffs.
Left Side:
Bottom - Buff bar, it also contains most of my AE damage spells.
Upper - Contains buffs that I couldn't fit on the bottom as well as some short buffs like Cheetah, Feral Tenacity, etc. This bar also houses all my mana regen items.
Right Side:
Cure Bar - As my primary bar, if needed I put effects that I am expecting on encounters in 1 and 2 while having my group cure at 3 always. The rest of the bar contains God Pets, SoW, Invis, etc.
Macro Cure Bar - I made this bar mostly for the Pawbuster Encounter. Contains 5 macros with cure to target effect. This bar also holds 2 macros for gear (DPS and Healing) as well as 2 macros for animal form (1.0 sec delay weapon and Epic weapon)
Potion Bar - Something I don't use as often. But all my potions I typically used are on this bar.
Rez Bar - Contains all rezzes, hibernate, emergency heal, and dehate spells. The emergency heals are here because I do not want to accidently hit them by accident and if I rez someone I want to get their health up quickly.
Portal Bar - Contains all portals, snare, and root spells.
Looks crazy I know, but its fuctional and works for me.
