Fouk

After obtaining Mythical, is there any point in going with dualwield or twohander in _any_ scenario for dps and stuff?

Just wondering, it seems to be obsolete.

If so, which weapon (twohander and offhand), which group setup and most of all, why?

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Pinski

No, there is no point, unless you get an Illusionist and have the never dropped War Axe 2.0.

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Vaux

In my experience you need about 65% double attack (and a decent fabled offhand) to replace the dps of 100% double attack with the mythical epic.

I've hit about 90% DA (90% crits) dual wielding with IA, jewel of animosity, and misc. buffs / gear and it's about 6-6.5kdps in ideal situations opposed to 5k with epic + shield. Not really a huge gain considering the avoidance loss, and the fact you're taking IA that could probably be better used elsewhere in the raid, but it is ultimately more damage.

Experimenting with 2H in SoH with agi line + 4 mobs at a time has led me to agree that the only 2H which could be worth the avoidance loss would be War Axe 2.0. Doombringer Pendulum + jewel + IA can occasionally put out a lucky 7-8k parse but it's more often ~5k. Skewed maybe by the difficulty in getting 4 mobs at once while sustaining DPS but for some reason 2H just never seems to parse consistently as high as you'd expect.