Mass Effect PC
So, I never played this on the 360, and I picked it up for the PC. Holy christ, big mistake.
The PC version has so many game breaking bugs, including fun little moments when you suddenly have no control of your character, yet action goes on around you just fine. You can't ESC out to the menus or anything, forcing you to kill the process in Task Manager. On top of that, there are random renderer errors that pop up a dialog box you can't click, nor can you interact with the game that's (again) running just fine. Killing the process is the only way out.
If you have SLI, you'll find that the game runs great, except for one section (for those of you that played, it's the Citadel Tower), which slows to a crawl. If you disable SLI, that section magically runs faster.
I have a few minor issues with it as well, like the lack of 360 pad support (though Bioware's reps made several posts to the forums swearing up and down that there would be support), a useless achievement system that's not connected to anything where it would matter, motion blur acting really weird on elevators, and other stuff.
Otherwise, I'm having fun. If you have a 360 and a PC, play the 360 version. Avoid this piece of shit port as if it sprayed airborne AIDS in your face.
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