Air compressor isn't a problem as long as there isn't condensation built up inside.
You can also get a liquid cleaning solution at some mom and pop computer stores that will REALLY clean the PCB.
But eh, compressed air should be enough.
well I have already did it to be sure i had pulled all the Cables 30 Min's a head of time. and for me it was a easy as well and help a lot. Dusting it has only helps as much and My glitches in all games as well as Crashes because off Overheat is goon so I'm happy...
Now to buy one so I don't have to borrow my friends lol